Patient-oriented Translational and Epidemiology Research


Most kidney disorders are currently diagnosed based on clinical assessment alone, and late diagnosis or misclassification often causes uncertainty in identifying the etiology of kidney diseases, as well as preventing timely diagnosis and treatment. Even within traditional clinical diagnostic categories, inter-individual variation in clinical presentation, disease progression and therapeutic response has long suggested heterogeneity that may be resolved with new molecular tools. Only recently, advances in high throughput genomic, proteomic, metabolomic and data sciences have begun to provide a more precise delineation of the molecular etiologies of kidney diseases, allowing reclassification based on primary molecular pathogenesis, and sometimes enabling targeted approaches to diagnosis and therapy. These new advances emerging in basic science laboratories frequently require rigorous clinical studies to enable their translation into clinical practice. The Division of Nephrology understands the significance of providing a more precise delineation of the molecular etiologies of kidney disease and is actively engaged in such efforts. The following are those faculty members conducting patient-oriented translational research in this area:

Andrew Bomback, M.D., M.P.H. is an Assistant Professor of Clinical Medicine at Columbia University Medical Center. Dr. Bomback’s research interests are focused on the epidemiology and treatment of rare immune-mediated or inflammatory glomerular diseases. He is either Principal or Co-Investigator in trials evaluating new agents for lupus nephritis, membranous nephropathy, IgA nephropathy, Alport syndrome, and C3 glomerulonephritis. He is a Co-Investigator in the NIDDK-sponsored CureGN study and multi-Principal Investigator in a NIMHD-sponsored R01 grant to study the role of genetic ancestry in the epidemiology and prognosis of membranous nephropathy, IgA nephropathy, and lupus nephritis in a multi-ethnic cohort of patients.

Anjali Ganda, M. D., M.S. is an Assistant Professor of Medicine. She is a graduate of the Columbia Internal Medicine and Nephrology training programs, and completed a CTSA-sponsored Masters in Patient Oriented Research/Biostatistics in 2010. Dr. Ganda’s translational research program is focused on mechanisms of accelerated cardiovascular disease in patients with CKD. She is the recipient of a 2013-2018 NIH/NIDDK K23 Patient Oriented Career Development Award and a 2013-2016 Louis V. Gerstner, Jr. Scholars Program Award from Columbia College of Physicians & Surgeons.

Sumit Mohan, M.D., M.S. is an Assistant Professor of Medicine and Epidemiology. Dr. Mohan’s primary area of interest is improving outcomes for patients with acute and chronic kidney disease. His current work is focused on outcomes in renal transplantation by developing strategies for improving access to transplantation, particularly for minority and disadvantaged individuals as well as improving outcomes following renal transplantation. He is also interested in identifying opportunities to improve organ allocation by optimizing utilization of marginal deceased donor kidneys.

Thomas Nickolas, M.D., M.S. is an Associate Professor of Medicine and is the Director for the Nephrology Fellowship Program. Dr. Nickolas’ research interests are in the skeletal effects of kidney disease and in the identification and development of biomarkers of acute and chronic kidney disease (AKI and CKD respectively). He has shown that fracture rates are more than 2-fold elevated in patients with CKD prior to being placed on dialysis. He then identified that in CKD, the predominant bone abnormality lies within the cortical compartment and that the cortical bone abnormality progressively worsens over time and is the main determinant of decreases in bone strength. He identified mechanisms of bone loss in kidney transplant recipients managed with early corticosteroid withdrawal. He is Principal Investigator of a double blinded placebo controlled randomized clinical trial to determine whether calcitriol mitigates bone loss during the first year of transplantation that is funded by the Coplon Foundation. Concurrently, he conducted the first clinical trials demonstrating that Neutrophil Gelatinase-Associated Lipocalin (NGAL) predicted acute kidney injury, dialysis and death of the patient within 7 days of sampling. He also demonstrated that NGAL was associated with rapidly progressive chronic kidney diseases that are associated with tubular disorders, such as HIV. He is Co-Investigator on an R01 to determine the effects of Pre-Exposure Prophylaxis for HIV prevention on the development of subclinical AKI and osteoporosis. As Director for the Nephrology Fellowship Program, he is intimately involved in selection of high quality candidates from the annual applicant pool and is responsible for providing them with programmatic guidance, support and career counseling throughout their training.
 
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